l1 element การใช้

• L1 elements also demonstrate widespread genomic coverage, with a largely random distribution of insertions.
• Whereas L1 elements diversify into several subclades, RTE-type LINEs are highly conserved, often constituting a single family.
• Of these, L1 elements for their proliferation make up 13 % of the human genome and have a copy number of around 1.5 million.
• A typical L1 element is approximately 6, 000 base pairs long and consists of two non-overlapping open reading frames ( ORF ) which are flanked by UTR and target site duplications.
• Recent estimates show the typical human genome contains on average 100 L1 elements with potential for mobilization, however there is a fair amount of variation and some individuals may contain a larger number of active L1 elements, making these individuals more prone to L1-induced mutagenesis.
• Recent estimates show the typical human genome contains on average 100 L1 elements with potential for mobilization, however there is a fair amount of variation and some individuals may contain a larger number of active L1 elements, making these individuals more prone to L1-induced mutagenesis.